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Titlebook: Chemical Mutagens; Principles and Metho Frederick J. Serres,Alexander Hollaender Book 1982 Springer Science+Business Media New York 1982 DN

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书目名称Chemical Mutagens
副标题Principles and Metho
编辑Frederick J. Serres,Alexander Hollaender
视频video
图书封面Titlebook: Chemical Mutagens; Principles and Metho Frederick J. Serres,Alexander Hollaender Book 1982 Springer Science+Business Media New York 1982 DN
描述New developments in the study of environmental mutagens continue to evolve in this rapidly emerging field. In Volume 7 of Chemical Mutagens, we have focused on various new techniques for the detection of genetic damage in somatic cells and germ cells of mammals and the use of lower eukaryotic microorganisms to detect aneuploidy as well as other types of genetic damage. Attention has also been given to the role of in vitro metabolic activation as a mechanism for modifying the genetic effects of different environmental chemicals. In a chapter on compar­ ative mutagenesis, reaction kinetics and their relationship to the mu­ tagenic action of monofunctional alkylating agents in higher eukaryotic organisms are examined. In another chapter, the pharmacology and toxicology of nitrites and nitrates, which are in widespread distribution in the environment, are discussed in detail. The books in this series have provided a mechanism for the publication of many important new developments in the study of the genetic effects of environmental chemicals. This series was launched by Dr. Alexander Hollaender who, beginning in 1971, edited Volumes 1-4 and then coedited Volumes 5-7. The success of his
出版日期Book 1982
关键词DNA; Mamma; Mitose; Nitrat; Nitrit; amino acid; biology; chromosome; metabolism; mouse; mutagen; protein
版次1
doihttps://doi.org/10.1007/978-1-4615-6625-0
isbn_ebook978-1-4615-6625-0
copyrightSpringer Science+Business Media New York 1982
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Microbial Metabolism of Environmental Chemicals to Mutagens and Carcinogens,s are mutagenic or carcinogenic only following metabolic conversion to activated* products, short-term test systems generally use a mammalian cell extract for . activation. This typically consists of the postmitochondrial 9000g* supernatant (S-9) fraction of liver prepared from rats treated with Aro
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Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology, status of an area with potentially important ramifications in regard to aspects of mutagenesis/carcinogenesis and, thus, in regard to public health. The reader will encounter citation of some older literature that appears neglected but merits reconsideration in the light of modern knowledge. The re
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The Relation between Reaction Kinetics and Mutagenic Action of Monofunctional Alkylating Agents in the same individual. In view of this diversity in response, a central question is whether relationships can be established for genetic effects of chemicals that are valid beyond the particular species, strain, and set of environmental conditions under which the correlations were obtained. This ques
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The Human Leukocyte Test System,cytogenetic test system “closest to man.” (2) Some special characteristics of stimulable leukocytes in contrast to all other types of tissue-culture systems provide a unique cell system for the study of a variety of problems concerning mechanisms of induction of chromosomal aberrations.
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