Titlebook: Chemical Mutagens; Principles and Metho Frederick J. Serres Book 1983 Plenum Press, New York 1983 Antigen.base.kinetics.mutagenesis.researc

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Detection of Effects of Mutagens in Human Populations,the consequences of genetic damage in somatic cells of exposed individuals. Among possible effects of somatic cell mutagenesis, the most notable is an increase in the incidence of cancer. The conceptual and experimental bases for associating cancer causation with somatic cell mutagenesis have recently been reviewed by Straus..

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The Mouse Spot Test As a Predictor of Heritable Genetic Damage and Other Endpoints, mammal as a test object. This chapter will examine available evidence on the ability of the spot test to predict the potency of an agent in causing .. Additional endpoints that might be predicted by spot-test prescreening will be examined more briefly.

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Mutational Analysis in Cultured Human-Hamster Hybrid Cells,elop short-term . tests that will provide reliable and scientifically sound means of assessing the mutagenic and carcinogenic potential of environmental agents so as to reduce harmful exposure to humans.

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