Titlebook: Chemical Mixtures and Combined Chemical and Nonchemical Stressors; Exposure, Toxicity, Cynthia V. Rider,Jane Ellen Simmons Book 2018 Sprin

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Physiologically Based Pharmacokinetic Modeling of Chemical Mixturesdosimetry simulations in risk assessment and in pharmaceutical sciences. Because this tool can use chemical and physiological information/data from different sources (i.e., in vitro, in vivo, in silico), it is also being increasingly used for mixture exposures, especially for mixtures containing che

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Mixture Experimental Designhere has been considerable progress over the past decades, further improvement is necessary both in the development and application of experimental designs to yield data suitable for quantitative analytic methods and in the implementation of appropriate statistical analyses. This chapter reviews the

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Book 2018k associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the

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