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Titlebook: Chemical Mixtures and Combined Chemical and Nonchemical Stressors; Exposure, Toxicity, Cynthia V. Rider,Jane Ellen Simmons Book 2018 Sprin

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书目名称Chemical Mixtures and Combined Chemical and Nonchemical Stressors
副标题Exposure, Toxicity,
编辑Cynthia V. Rider,Jane Ellen Simmons
视频video
概述Presents the available mixture models in a clear and simple way, allowing readers to apply tools to their own research.Includes novel methods for prioritizing mixtures for study.Surveys what is known
图书封面Titlebook: Chemical Mixtures and Combined Chemical and Nonchemical Stressors; Exposure, Toxicity,  Cynthia V. Rider,Jane Ellen Simmons Book 2018 Sprin
描述In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments.  Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science,risk assessment, and statistics.
出版日期Book 2018
关键词Chemical interaction; Combined exposures; Cumulative toxicology; Mixture model; Non-chemical stressor; Ri
版次1
doihttps://doi.org/10.1007/978-3-319-56234-6
isbn_softcover978-3-030-09617-5
isbn_ebook978-3-319-56234-6
copyrightSpringer International Publishing AG 2018
The information of publication is updating

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Considerations for Measuring Exposure to Chemical Mixturesdied with regard to environmental occurrence and to toxicity. If a commercial chemical standard does not exist for a given chemical, then little to no quantitative data likely exists for that chemical. This chapter discusses exposures to organic chemical mixtures, lists necessary considerations for
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Adverse Outcome Pathways to Support the Assessment of Chemical Mixtures the use of less costly alternative techniques. The adverse outcome pathway (AOP) concept has emerged as a scaffold for organizing mechanistic information from these methods. Two main elements – key events (KEs) and key event relationships (KERs) – are utilized to describe the underlying mechanism o
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Mixtures: Contrasting Perspectives from Toxicology and Epidemiologyinto the commonalities and differences in the viewpoint and methods that toxicologists and epidemiologists use to investigate health effects of mixtures. Ways in which these two important disciplines can work together are suggested.
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