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Titlebook: Chemical Genomics; Small Molecule Probe S. Jaroch,H. Weinmann Conference proceedings 2006 Springer-Verlag Berlin Heidelberg 2006 Chemical b

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书目名称Chemical Genomics
副标题Small Molecule Probe
编辑S. Jaroch,H. Weinmann
视频video
概述Illustrates current progress in chemogenomics, diversity-oriented synthesis, chemical biology, chemical genomics, and.screening technologies
丛书名称Ernst Schering Foundation Symposium Proceedings
图书封面Titlebook: Chemical Genomics; Small Molecule Probe S. Jaroch,H. Weinmann Conference proceedings 2006 Springer-Verlag Berlin Heidelberg 2006 Chemical b
描述.Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology..
出版日期Conference proceedings 2006
关键词Chemical biology; Chemical genomics; Chemogenomics; Diversity-oriented synthesis; Screening; biology; natu
版次1
doihttps://doi.org/10.1007/978-3-540-37635-4
isbn_softcover978-3-662-51797-0
isbn_ebook978-3-540-37635-4Series ISSN 0947-6075
issn_series 0947-6075
copyrightSpringer-Verlag Berlin Heidelberg 2006
The information of publication is updating

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Tamoxifen-Based Probes for the Study of Estrogen Receptor-Mediated Transcription,y pathways, analogs of 4-hydroxytamoxifen were synthesized with variations in the basic side chain. In vitro binding assays and cell-based luciferase reporter gene assays confirm that all the derivatives have high affinity for the receptor and high potency at repressing direct estrogen receptor-mediated transcription.
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Protein Structure Similarity Clustering and Natural Product Structure as Guiding Principles for Cheoid dehydrogenases based on the structure of a naturally occurring Cdc25 inhibitor. The efficiency of making use of the scaffolds of natural products as biologically prevalidated starting points for the design of compound libraries is further highlighted by the development of benzopyran-based FXR ligands.
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