Titlebook: Chemical Genomics; Small Molecule Probe S. Jaroch,H. Weinmann Conference proceedings 2006 Springer-Verlag Berlin Heidelberg 2006 Chemical b

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Gasstoffwechsel und Elektrolyte,target. Because of the almost infinite number of drug-like organic molecules, this is an impossible task. Therefore chemogenomics has been defined as the investigation of classes of compounds (libraries) against families of functionally related proteins. In this definition, chemogenomics deals with

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Beiträge zur Kardiologie und Angiologieanscription though a number of different pathways. As part of an effort to develop reagents that selectively target specific transcriptional regulatory pathways, analogs of 4-hydroxytamoxifen were synthesized with variations in the basic side chain. In vitro binding assays and cell-based luciferase

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Beiträge zur Kardiologie und Angiologietopology in the ligand-sensing cores of protein domains can be exploited for the design of small-molecule libraries in the development of inhibitors and ligands. Thus, a novel strategy of clustering protein domain cores based exclusively on structure similarity considerations (protein structure simi

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