Titlebook: Checkpoint Responses in Cancer Therapy; Wei Dai Book 2008 Humana Press 2008 DNA.apoptosis.biotechnology.cancer.cancer research.cancer ther

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CDK Inhibitors as Anticancer Agents, driven reactions that result in cell division and the generation of new cells. The cell cycle is regulated by kinases such as cyclin-dependent kinases (CDKs), and non-CDKs, which include the Aurora and Polo-like kinases, as well as checkpoint proteins and mitotic kinesins. The CDK family of serine-

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Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin Structf cancer cell lines, and inhibit tumor growth in vivo. The antiproliferative effects of HDACis are caused by drug induced G1 or G2 phase cell cycle arrests. They also promote aberrant mitosis, which in cycling cells can result in the rapid onset of apoptosis. Hyperacetylation of the constitutive cen

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