Titlebook: Cerebral Signal Transduction; From First to Fourth Maarten E. A. Reith Book 2000 Springer Science+Business Media New York 2000 Alzheimer.al

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Signal Transduction Abnormalities in Bipolar Affective Disordera or hypomania and depression, which afflicts an estimated 1% of the general population .. Evidence from family, genetic, and psychobiological studies indicates a major role for biological factors in the genesis, expression, and perpetuation of BD .. Recent advances arising from research on transmem

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Messengers in Opioid Dependence morphine and its derivatives still remain the most potent class of analgesics, and they have clear therapeutic indications despite a considerable number of adverse side effects. However, some opioid compounds also represent an important public health problem because heroin, a diacetylated morphine

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The 5-HT1B Knockout Mousese. In human males, for example, 40–50% of the variance in alcohol preference appears to be genetically determined, according to twin studies, adoption studies, and familial studies .. In mice and rats, inbred strains display marked differences in responses to alcohol, cocaine, and other drugs of ab

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Protein Kinase C Signaling in Learning and Memoryd, hence, their function. The discovery of a novel, cyclic nucleotide-independent, protein kinase took place relatively recently in the late 1970s (for a historical review on PKC in learning and memory, . ref. . and references therein). In 1977, co-workers from the Nishizuka group at Kobe University

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The NO Signaling Pathway in the Brainent, regeneration, synaptic plasticity, and regulation of gene expression, but also in pathological conditions in which deregulated excessive production of NO leads to neural injury. Furthermore, rapid progress is now being made in understanding the regulation of NOS activity and the cellular and mo

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Signal Transduction Abnormalities in Bipolar Affective Disorderplicating disturbances in an array of intracellular signaling disturbances, including adenosine 3′, 5′-cyclic monophosphate (cAMP) and calcium and phosphoinositide (PPI) signaling cascades in BD as depicted in Fig. 1. We also describe results from complementary investigations on the pharmacological

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The 5-HT1B Knockout Mousent inbred strains and QTL analysis has allowed the identification of several genetic loci that are responsible for most of the strain differences in preference for different categories of drugs of abuse, including the psychostimulant cocaine, the sedative alcohol, and the opiate morphine .,.. Theref