| 书目名称 | Central Neurotransmitter Turnover | | 编辑 | C. J. Pycock,P. V. Taberner | | 视频video | | | 图书封面 |  | | 描述 | The concept of chemical transmission in the central nervous system has taken some time to be generally accepted, but an increasing number of compounds are now being recognized as hav ing a transmitter role in the brain. The acetylcholine system was the first to be discovered in the periphery and its charac teristic features of storage of transmitter in vesicles in the nerve terminal, its electrically-evoked release and rapid extra neuronal breakdown were considered to be necessary criteria for any neurotransmitter candidate. The subsequent elucidation of the noradrenergic system made it apparent that rapid enzymatic breakdown was not essential for a released transmitter, and the possibility of high-affinity re-uptake processes became establ ished as an alternative means of terminating the synaptic actions of a transmitter. With the eventual acceptance of the amino acids as excitat ory or inhibitory transmitters, the requirement for a transmit ter to be present in a low concentration overall (although locally concentrated in specific terminals) also had to be discarded. This necessitated the additional concept of specif ic metabolic pools with different functions being locate | | 出版日期 | Book 1981 | | 关键词 | brain; catecholamines; nervous system; system; time | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-9778-0 | | isbn_softcover | 978-1-4615-9780-3 | | isbn_ebook | 978-1-4615-9778-0 | | copyright | C.J. Pycock and P.V. Taberner 1981 |
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发表于 2025-3-21 16:47:50
