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Titlebook: Central Functions of the Ghrelin Receptor; Jeanelle Portelli,Ilse Smolders Book 2014 Springer Science+Business Media New York 2014 addicto

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发表于 2025-3-21 18:42:53 | 显示全部楼层 |阅读模式
书目名称Central Functions of the Ghrelin Receptor
编辑Jeanelle Portelli,Ilse Smolders
视频videohttp://file.papertrans.cn/224/223184/223184.mp4
概述The first book to present a comprehensive overview of the ghrelin receptor.Describes the role of ghrelin in feeding and adictive behavior, memory, sleep, and arousal.Explores options for bringing sele
丛书名称The Receptors
图书封面Titlebook: Central Functions of the Ghrelin Receptor;  Jeanelle Portelli,Ilse Smolders Book 2014 Springer Science+Business Media New York 2014 addicto
描述The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson’s disease, epilepsy, anxiety and depressi
出版日期Book 2014
关键词addicton; constitutive receptor activity; food intake; ghrelin receptors; pathophysiology
版次1
doihttps://doi.org/10.1007/978-1-4939-0823-3
isbn_softcover978-1-4939-5534-3
isbn_ebook978-1-4939-0823-3Series ISSN 1048-6909 Series E-ISSN 2524-6488
issn_series 1048-6909
copyrightSpringer Science+Business Media New York 2014
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发表于 2025-3-21 21:01:22 | 显示全部楼层
https://doi.org/10.1007/978-3-642-68202-5e concept that ghrelin regulates both homeostatic and hedonic aspects of feeding, and evidence from different studies confirms that ghrelin promotes food intake via diverse mechanisms. Of note, derangements in the ghrelin/ghrelin receptor 1a system have been reported in several eating disorders, inc
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发表于 2025-3-22 08:06:29 | 显示全部楼层
W. Seipp,D. Haina,V. Justen,W. Waidelichard induced by other additive drugs such as nicotine, cocaine and amphetamine also involve ghrelin and its receptor. Human genetic data support a role for ghrelin in drug reward. Polymorphisms in ghrelin-related genes are associated with increased alcohol intake, smoking as well as amphetamine depen
发表于 2025-3-22 12:26:27 | 显示全部楼层
Wilhelm Waidelich (Professor, Head)rmore, single nucleotide polymorphisms (SNPs) within genes encoding ghrelin, i.e., the preproghrelin gene (.), and the ghrelin receptor, i.e., growth hormone secretagogue receptor gene (.), have been associated with alcohol drinking behaviors and other phenotypic variables related to alcohol depende
发表于 2025-3-22 14:58:19 | 显示全部楼层
https://doi.org/10.1007/978-3-642-68344-2ding humans is sparse and less conclusive, sometimes even suggesting memory-impairing effects of ghrelin. However, the increasing body of evidence demonstrating memory-supporting and neuroprotective effects in rodent models calls for further research that elucidates ghrelin’s effects on human cognit
发表于 2025-3-22 18:36:26 | 显示全部楼层
G. C. Amstutz,G. Frenzel,A. Goresyceptor at extra-hypothalamic brain regions to exert indirect control over central responses to stress and over brain pathways related to anxiety and depression. In this chapter, I discuss the background and potential mechanisms for ghrelin and ghrelin receptor’s role in regulating stress and stress-
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The Role of the Ghrelin Receptor in Appetite and Energy Metabolismndent feed-forward system. This model of synaptic plasticity ensures sustained NPY firing during periods of negative energy balance. Taken together, we detail a number of novel mechanisms through which ghrelin signaling via the GHSR1a maintains high NPY neuronal activity in order to promote food int
发表于 2025-3-23 05:41:52 | 显示全部楼层
Central Ghrelin Receptors and Food Intakee concept that ghrelin regulates both homeostatic and hedonic aspects of feeding, and evidence from different studies confirms that ghrelin promotes food intake via diverse mechanisms. Of note, derangements in the ghrelin/ghrelin receptor 1a system have been reported in several eating disorders, inc
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