Titlebook: Cells, Membranes, and Disease, Including Renal; Including Renal Eric Reid,G. M. W. Cook,J. P. Luzio Book 1987 Plenum Press, New York 1987 O

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Marek Kolmer,Jakub S. Prauzner-Bechcickiting oils and cosmetics). Methapyrilene induces liver tumours in rats, but not in other species, and several structurally close analogues are not carcinogenic. These analogues do not induce mitochondrial proliferation, nor does methapyrilene in species other than the rat.

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Drug-Induced Mitochondrial Proliferationting oils and cosmetics). Methapyrilene induces liver tumours in rats, but not in other species, and several structurally close analogues are not carcinogenic. These analogues do not induce mitochondrial proliferation, nor does methapyrilene in species other than the rat.

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Studies on the Mechanisms of Changes Produced in the Liver, Thyroid, Pancreas and Kidney by Hypolipisomes which were filled with material staining as for lipofuscin. The pancreas showed exocrine-cell hyperactivity, and with prolonged treatment the islets did not show the hypertrophy normally observed in ageing rats. All the alterations may well relate to alterations in fat metabolism.

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Investigation of Subcellular Derangements in Human Biopsy Materialmical investigations. Studies of organelle abnormalities can be quantitatively assessed by marker enzyme analysis (e.g. N-acetyl-β-glucosaminidase and acid phosphatase for lysosomes, lactate dehydrogenase for cytosol) in combination with subcellular fractionation by density-gradient centrifugation.

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Analytical Subcellular Studies in Alcoholic Liver Diseaseclude mitochondrial, lysosomal, peroxisomal and e.r.* changes; but whether these alterations are adaptive or pathological remains to be determined. In addition, lipid accumulation is a major feature of alcohol toxicity; but the nature and, in particular, the subcellular localization of the lipid and