Titlebook: Cell Therapy for Perinatal Brain Injury; Haruo Shintaku,Akira Oka,Makoto Nabetani Book 2018 Springer Nature Singapore Pte Ltd. 2018 Stem c

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https://doi.org/10.1007/BFb0040988r cell-based therapies for perinatal brain injury. Nearly 20 studies in models of perinatal brain injury, most of which are rodent models of neonatal hypoxia-ischemia, have histologically and functionally demonstrated beneficial effects of systemic administration of HSCs and the related cell fractio

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Helmuth Goldberg,Fredi Tröltzschy starts and proceed to Consensus 2010 in which hypothermia therapy should be recommended for newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE). Next I talk about how hypothermia therapy spreads and could be standardized on the guideline and nationwide online registry system in

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Karl-Heinz Hoffmann,Werner Krabsed in the United States (Michael et al. J Pediatr 164:973–979, 2014). We have thus decided to initiate a similar clinical trial in Japan and set obstetric criteria for the indication of cell therapy. Written consent for UCB collection was obtained following successful collection, as the cases includ

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https://doi.org/10.1007/BFb0044338plantation in infants with HIE. We selected patients for UCB stem cell transplantation based on following criteria; (1) moderate or severe HIE according to the classification of Sarnat II or III and Thompson score ≥10 points, (2) gestational age ≥36 weeks, (3) body weight at birth >1800 g, (4) born

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Optimization of Discrete Time Systemsovery. Recently, accumulating evidences suggest that neurogenesis occurs even in the adult brain and patients may have a chance for functional recovery after stroke. Although most stroke-induced neural stem cells cannot survive in the poststroke brain, we demonstrated that therapeutic angiogenesis a

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Optimization of Discrete Time Systemsurring at delivery or perinatally. To prevent or reduce the neurogenic disabilities in cerebral palsy, therapies using hypothermia, autologous cord blood infusion, and recently, mesenchymal stromal cells (MSCs) have been applied. MSCs can be obtained from fetal appendages such as cord blood, umbilic