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Titlebook: Cell Therapy for Perinatal Brain Injury; Haruo Shintaku,Akira Oka,Makoto Nabetani Book 2018 Springer Nature Singapore Pte Ltd. 2018 Stem c

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发表于 2025-3-21 17:57:51 | 显示全部楼层 |阅读模式
书目名称Cell Therapy for Perinatal Brain Injury
编辑Haruo Shintaku,Akira Oka,Makoto Nabetani
视频video
概述Includes reviews of current clinical trial results and procedures for the relevant topics.Promotes a better understanding of cell therapy.Written by leading researchers in this exciting and rapidly ad
图书封面Titlebook: Cell Therapy for Perinatal Brain Injury;  Haruo Shintaku,Akira Oka,Makoto Nabetani Book 2018 Springer Nature Singapore Pte Ltd. 2018 Stem c
描述.This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. ..These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. ..The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. .Cell Therapy for Neonatal Ischemic Disease .will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to furtherexplore this evolving therapy..
出版日期Book 2018
关键词Stem cell therapy; CD34 cell; Neural stem cell; Mesenchymal stem cell; Ischemic disease; Clinical Trial
版次1
doihttps://doi.org/10.1007/978-981-10-1412-3
isbn_softcover978-981-13-3820-5
isbn_ebook978-981-10-1412-3
copyrightSpringer Nature Singapore Pte Ltd. 2018
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发表于 2025-3-22 01:08:46 | 显示全部楼层
Pathophysiology and Pathology of Neonatal Hypoxic-Ischemic Encephalopathy,unique. The mode of cell death includes necrosis and apoptosis. Necrosis occurs in conditions of primary energy failure following the initial injury. On the other hand, apoptosis occurs days after the initial injury. The damaged area in the brain depends on the mode of injury. Severe and prolonged i
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Hematopoietic Stem Cells for Perinatal Brain Injury,r cell-based therapies for perinatal brain injury. Nearly 20 studies in models of perinatal brain injury, most of which are rodent models of neonatal hypoxia-ischemia, have histologically and functionally demonstrated beneficial effects of systemic administration of HSCs and the related cell fractio
发表于 2025-3-22 16:23:46 | 显示全部楼层
Umbilical Cord-Derived Mesenchymal Stromal Cells for Perinatal Brain Injury,ons including (1) no adverse events during collection, (2) ease of collection even after cord blood (CB) collection or failure to collect CB, (3) minimal ethical controversy, (4) multipotency to differentiate into various cell types, and (5) low immunogenicity with significant immunosuppressive abil
发表于 2025-3-22 17:31:10 | 显示全部楼层
Other Tissues-Derived Mesenchymal Stem Cells for Perinatal Brain Injury, in preclinical models of HIE. However, despite their neural commitment, ethical concerns hinder the use of postmortem human brains as a source of NSPCs in future clinical applications. Furthermore, intracerebral administration is an invasive procedure..Stem cells originating from nonneural tissues
发表于 2025-3-22 23:03:49 | 显示全部楼层
CD34+ Cell in Cord Blood and Neonates,opoietic and non-hematopoietic stem/progenitor cells. This chapter focuses on recent progresses in stem cell biology on cord blood cells. During embryonic development, expression of CD34 is tightly regulated in a spatial and temporal manner. Subpopulations of CD34. cells in cord blood have been char
发表于 2025-3-23 01:29:26 | 显示全部楼层
The History of Hypothermia Therapy for Perinatal Ischemic Brain Injury,y starts and proceed to Consensus 2010 in which hypothermia therapy should be recommended for newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE). Next I talk about how hypothermia therapy spreads and could be standardized on the guideline and nationwide online registry system in
发表于 2025-3-23 06:55:08 | 显示全部楼层
Clinical Procedure of Cell Therapy: Cord Blood Collection,ed in the United States (Michael et al. J Pediatr 164:973–979, 2014). We have thus decided to initiate a similar clinical trial in Japan and set obstetric criteria for the indication of cell therapy. Written consent for UCB collection was obtained following successful collection, as the cases includ
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