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Titlebook: Cell Therapy; Yasuo Ikeda (Professor),Jun-ichi Hata (Professor), Conference proceedings 2000 Springer-Verlag Tokyo 2000 Carcinom.Vivo.bone

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Gene Encoding Squamous Cell Carcinoma Antigen Recognized by Cytotoxic T Lymphocytesby the HLA-A26-restricted CTLs, and was able to induce in vitro the HLA-A26-restricted and SART-1.. tumor-specific CTLs from peripheral blood mononuclear cells (PBMCs) of cancer patients. On the other hand, the SART1 peptide at position 690–698 was recognized by the HLA-A24-restricted CTLs, and also
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Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clonespriately to sites of disease. It is anticipated that additional studies will define disease settings in which T-cell therapy can be beneficial and further elucidate the requirements for effective immunotherapy in humans.
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Adoptive Transfer of Polyclonal, EBV-Specific Cytotoxic T-Cell Lines for the Prevention and Treatmenymphomas most commonly occur in patients who are severely immunosuppressed and hence do not use immune evasion strategies. We have shown that these tumors can be treated effectively with infusions of virus-specific CTLs. The tumors occurring in patients who are immunocompetent or only mildly immunos
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Immunotherapy of Melanoma Using Dendritic Cellsissions). Immune escape mechanisms were evident at various levels of antigen presentation, including defects in expression of proteasomal antigens, TAP deficiency, melanoma antigen loss variants, and absent expression of relevant HLA surface molecules. DC vaccination for induction of an antitumor re
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Immunotherapy of Melanoma Using T-Cell-Defined Antigensnical trials have been performed in the Surgery Branch of the National Cancer Institute, USA. The immunization with the gp100. peptide that was modified to have high HLA-A2-binding affinity, along with incomplete Freund’s adjuvant and interleukin-2, resulted in 42% response rate in patients with mel
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Isolation and Characterization of CD34-Low/Negative Mouse Hematopoietic Stem Cells by dividing very slowly. Furthermore, analysis of aged mice revealed more than tenfold increase in absolute number of CD34.KSL cells. Those CD34.KSL cells in aged mice appeared to include HPP-CFC at an equivalent frequency with those in younger mice. These data support our previous notion that CD34
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Ex Vivo Expansion of Human Hematopoietic Stem Cellsfold in serum-free culture by day 14. More than 100-fold expansion of total and multipotential progenitors was obtained from CD34.IL-6R. cells but not from CD34.IL-6R. cells in culture with sIL-6/IL6/SCF. Addition of thrombopoietin (TPO) to culture with sIL-6R/IL-6/SCF or sIL-6/IL-6/FL significantly
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Molecular Genetics of Acute Promyelocytic Leukemia: A Rationale for “Transcription Therapy” for Cancathogenesis allows the development of new therapeutic approaches. In particular, the recent elucidation of the molecular mechanisms underlying the pathogenesis of acute promyelocytic leukemia has allowed us to propose and exploit what we regard as a new concept for the treatment of cancer, which we
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