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Titlebook: Cell Therapy; Yasuo Ikeda (Professor),Jun-ichi Hata (Professor), Conference proceedings 2000 Springer-Verlag Tokyo 2000 Carcinom.Vivo.bone

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A Novel Acute Promyelocytic Leukemia Model: From Cell to Murine System patients achieve complete remission by the treatment of all-. RA; however, clinical remissions are usually of brief duration, and these patients often develop RA-resistant disease. The mechanisms of RA resistance in APL cells are poorly understood, and most clinical approaches have not been success
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Phase 1 Trial of Retroviral-Mediated Transfer of the Human MDR-1 in Patients Undergoing High-Dose Ch-sensitive drugs such as the vinca alkaloids, anthracyclines, podophyllotoxins, and taxanes. In this report of a phase 1 clinical study performed at the Columbia-Presbyterian Medical Center, we demonstrate the safety and efficacy of transfer of the human multiple drug resistance (MDR) gene into hema
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Basic Studies Toward Hematopoietic Stem Cell Gene Therapyare an ideal target for gene therapy. Retroviral vectors are predominantly used for transduction of HSCs, but the gene transfer efficiency is extremely low. Several efforts have been made at achieving clinically relevant gene transfer efficiencies. First, new cytokines such as Flt-3 ligand and throm
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Ex Vivo Expansion of Hematopoietic Cells neutropenia following transplantation. To date, no clinical studies using ex vivo expanded cells have demonstrated any decrease in the time to neutrophil or platelet recovery, although a number of clinical studies have been performed using a variety of growth factor cocktails and culture conditions
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