Titlebook: Cell Immortalization; Alvaro Macieira-Coelho Book 2000 Springer-Verlag Berlin Heidelberg 2000 Cell immortalization.Krebs.Seneszenz.aging.b

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Shalaka Sharad Shah,Shilpa ShindeIts effect on immortalization is particularly striking in human cells. Mouse cells have a quite limited life span in culture (approximatelyl0–20 generations) but can spontaneously become immortal at a measurable frequency; infection with wild-type SV40 results in almost 100% occurrence (Tevethia et

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Olympic Games and Global Cities reflect the ability to reproduce indefinitely, since the ancestry of each cell presumably traces back, in an unbroken lineage for over 3 billion years, to the origin of life. As pointed out by Avise (1993), it is not actually cells which are immortal, but cell lineages.

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Oracle GoldenGate HUB Architecture,the number of times cells divide rather than the calendar time elapsed. The restricted replicative capacity of normal cells which confers them the mortal divisional phenotype is widely accepted as the most consistent manifestation of cellular aging. Relevance of in vitro life span of cells to in vivo aging is evidenced by

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Cellular Mortality and Immortalization: A Complex Interplay of Multiple Gene Functions,the number of times cells divide rather than the calendar time elapsed. The restricted replicative capacity of normal cells which confers them the mortal divisional phenotype is widely accepted as the most consistent manifestation of cellular aging. Relevance of in vitro life span of cells to in vivo aging is evidenced by