Titlebook: Cell Cycle Deregulation in Cancer; Greg H. Enders Book 2010 Springer Science+Business Media, LLC 2010 DNA.biology.cancer.cancer therapy.ce

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Mitotic Checkpoint and Chromosome Instability in Cancerpromoting complex/cyclosome (APC/C). The CIN phenotype of many cancer cell lines may be attributed to the lack of a robust mitotic checkpoint as these cells fail to arrest in response to microtubule inhibitors such as taxol and nocodazole. Interestingly, mutations in the essential mitotic checkpoint