书目名称 | Cell Cycle Checkpoints | 副标题 | Methods and Protocol | 编辑 | Willis X. Li | 视频video | http://file.papertrans.cn/223/222780/222780.mp4 | 概述 | Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes supplementary materia | 丛书名称 | Methods in Molecular Biology | 图书封面 |  | 描述 | .Cell cycle checkpoints control the fidelity and orderly progression of eukaryotic cell division. By controlling the orderly progression of critical cell cycle events such as DNA replication and chromosome segregation and ensuring proper repair of damaged DNA, cell cycle checkpoints function to ensure genome integrity. Mechanisms of checkpoint controls are not only the research focus of investigators interested in mechanisms that regulate the cell cycle, but are also the interests of researchers studying cancer development as it is increasingly clear that loss of cell cycle checkpoints, which leads to genomic instability as a result, is a hallmark of tumorigenesis. .Cell Cycle Checkpoints: Methods and Protocols. provides detailed descriptions of methodologies currently employed by researchers in the field, including those commonly used in the mammalian, yeast, .C. elegans, Drosophila., and .Xenopus. model systems. Each chapter describes a specific technique or protocol, such as a method to induce cell cycle checkpoints in a particular model system, to synchronize a population of cells to allow observations of cell cycle progression, to identify genes involved in checkpoint regulati | 出版日期 | Book 2011 | 关键词 | DNA damage checkpoints; apoptosis; cell cycle progression; checkpoint kinases; eukaryotic cell division; | 版次 | 1 | doi | https://doi.org/10.1007/978-1-61779-273-1 | isbn_softcover | 978-1-4939-6181-8 | isbn_ebook | 978-1-61779-273-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 | issn_series | 1064-3745 | copyright | Springer Science+Business Media, LLC 2011 |
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