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Titlebook: Cell Biology and Pathology of Myelin; Evolving Biological Bernhard H. J. Juurlink,Richard M. Devon,Valerie M Book 1997 Springer Science+Bu

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Do Secretory Pathway Snare Proteins Mediate Myelinogenesis? synthesizes a vast amount of myelin membrane, in the range of 5,000–50,000 mm. per cell per day (Pfeiffer et al., 1993). In the neo-natal rat brain, or example, the mg of dry weight or myelin increases 600% from P0 to P30 and 1800% by P180; over this same time period total brain weight increases by
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Expression of the PLP Gene and a PLP-LacZ Transgene in Oligodendrocytesis a serious neurobiological problem (Raine, 1984). Central nervous system (CNS) myelin is a differentiation of the oligodendrocyte plasma membrane, which is produced during a relatively narrow time period in the early postnatal rodent brain. This differentiation program can be studied extensively i
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Developmental Regulation of Schwann Cell Precursors and Schwann Cell Generationsen and Mirsky, 1992; Le Douarin et al., 1991; Marusich and Weston, 1991). The other main glial types in the peripheral nervous system (PNS), are also thought to be derived from the crest. This includes the teloglia associated with somatic motor terminals, satellite cells associated with neuronal ce
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Protein Kinase C Regulates Process Formation by Oligodendrocytesathological processes. In many cases, the insults are continuous and recurring but despite this, remyelination can occur, as it does in MS although incomplete in its extent (Raine et al., 1981; Ghatak et al., 1989; Prineas et al., 1989, 1993; Raine and Wu, 1993; Bruck et al., 1994). Stimuli to enhan
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Mechanism of Adhesion-Induced Regeneration/Differentiation of Oligodendrocytesng fast nerve conduction. The advent of myelin marked an evolutionary milestone for it allowed the existence of higher organisms; at the same time, an irrevocable seal of myelin dependence was established. Any perturbation of the normal functioning of OLGs that results in dysmyelination will lead to
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Structure and Function of Myelin, an Extended and Biochemically Modified Cell Surface Membraneheaths where dynamic processes such as trans-membrane signaling and ion flux are likely to occur. The first part of this article consists of a brief overview the principal proteins in the compact myelin and myelin-related membranes, respectively. Since glycoproteins are important components of plasm
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Mutations of the Proteolipid Protein Genes generated which lacks 35 residues from the intracellular loop region (Nave et al., 1987a). DM20 is less abundant than PLP in compacted myelin but constitutes the more prevalent isoform in early CNS development (Dickinson et al., 1996) and in some non-glial cells (the function of proteolipids outsi
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