Titlebook: Cell Activation and Apoptosis in HIV Infection; Implications for Pat Jean-Marie Andrieu,Wei Lu Book 1995 The Editor(s) (if applicable) and

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Investigations on Autologous T-Cells for Adoptive Immunotherapy of Aids,23 x 10. lymphocytes, containing 1.82 x 10. CD4+, 3.23 x 10. CD8+ T-lymphocytes and 8.39 x 10. CD34+ peripheral blood progenitor cells (PBPC) were be obtained by continuous flow cytapheresis (CFC) in 15 asymptomatic HIV infected patients (CD4-count >350/mm.) The CD4/CD8 ratio (mean: 0.53, SD: ±0.15)

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The Role of Surface CD4 in HIV-Induced Apoptosis,on in asymptomatic infection is greater than previously thought and HIV may directly account for a significant proportion of the CD4+ T cell depletion seen in AIDS (.; .; .; .). HIV-induced apoptosis may be an important contributor to this depletion. Several mechanisms have been proposed to explain

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Programmed Death of T Cells in the Course of HIV Infection,s, eventually leading to the acquired immune deficiency syndrome (AIDS). Importantly, even before CD4+ T-cell numbers start to decline, functional abnormalities of T cells can be demonstrated in asymptomatically infected individuals. Both CD4+ and CD8+ T-cell function such as IL-2 production and pro

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Apoptosis During HIV Infection,s, recent reports indicate that these defects may be due to the inappropriate triggering of activation-induced cell death or apoptosis in T cells from such individuals whenstimulated with specific antigen or certain mitogens (.., 1992; .., 1992; .; Oyaizu ., 1993). Thus, the progressive depletion of

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From Cell Activation to Cell Depletion, induce in about ten years a progressive and complete loss of immune competence in the infected host by causing the loss of the lymphocyte population that plays a central role in the control of the immune response, the CD4. T helper cells..