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Titlebook: Cavernomas of the CNS; Basic Science to Cli Ondřej Bradáč,Vladimír Beneš Book 2020 Springer Nature Switzerland AG 2020 cavernous malformati

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is condition, to special patient groups such as children and pregnant women. Therefore, it is an indispensable resource for neurovascular surgeons, neurosurgical residents and neurologists..978-3-030-49408-7978-3-030-49406-3
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Molecular Biology of CCM,controlling endothelial permeability and angiogenesis. Additionally, each of the CCM proteins have their own biological roles in a range of basic cellular processes including apoptosis, migration, polarization, and cell adhesion. Mutations in PDCD10 tend to result in a more aggressive form of the di
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Presentation,isk of ICH during untreated follow up is around 3.8% for patients with non-brainstem CCMs presenting without ICH or NH-FND, around 8.0% forpatients with brainstem CCMs presenting without ICH or NH-FND, around 18.4% for patients with non-brainstem CCMs presenting with ICH or NH-FND, and around 30.8%
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Natural History of Cavernous Malformations, the cavernomas have been identified to date (Akers et al., Neurosurgery 80(5):665–680, 2017). When their mutations express, loss of respective proteins leads to formation of the lesion, with dilated thin-walled sinusoids or caverns covered by a single layer of endothelium that has undeveloped inter
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Surgery of Deep-Seated Cavernous Malformations,ment of adjacent structures that might stand in the way to this deep location. Surgical cases of hypothalamic CMs which are not discussed in this chapter are currently limited in the literature to a few case reports, and therefore the surgical resection of hypothalamic CMs is a great unknown. Out of
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Stereotactic Radiosurgery of Cavernous Malformations,e think that the key for proper interpretation of results is not only the application of modern treatment protocols, but the understanding of the natural history of CCMs. Based on our current understanding of natural history, hemispheric lesions appear to be more benign with lower annual bleed rate
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