Titlebook: Cartilage; Volume 3: Repair Str Susanne Grässel,Attila Aszódi Book 2017 Springer International Publishing AG 2017 biomaterial.mesenchymal s

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The Role of Platelet-Rich Plasma in Cartilage Repair,Among the available strategies, platelet-rich plasma (PRP), an autologous blood-derived concentrate rich in growth factors, is currently the most exploited biological approach for conservative management (simple intra-articular injections) and as an augmentation during surgical procedures. It has be

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Gene Transfer Strategies for Articular Cartilage Repair,ge injury resulting from acute trauma or during osteoarthritis. The focus of this chapter is to examine the benefits of gene therapy to improve cartilage repair in such lesions, based on promising experimental and clinical evidence in relevant models in vivo using growth, transcription, and signalli

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Collaborative Practice Research cartilage included. Moreover, MSCs are potentially accessible in high quantities with low donor site morbidity and reasonable cartilage-forming capacity. In 1998, Johnstone et al. (Exp Cell Res 238(1):265–272) were the first that proposed an effective protocol to chondrogenically differentiate MSCs

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Collaborative Practice Research function. Causal therapies are still challenging, and to date various cell biological methods applying chondrocytes or mesenchymal stem cells only generate fibrocartilaginous repair tissue with less good mechano-biological properties..In osteoarthritis and rheumatoid arthritis, a specific cell type

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Collaborative Practice Researchfar lacked an easily accessible cell source for cell therapies and in vitro models. The attractiveness of induced pluripotent stem (iPS) cells for cartilage regeneration roots from their immense expandability and their intrinsic ability to give rise to any adult tissue including stable hyaline carti