Titlebook: Cardiovascular System; Robin G. Shanks Textbook 1980Latest edition Macmillan Publishers Limited 1980 cardiovascular.cardiovascular system.

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Methods for Assessment of the Effect of Drugs on Cerebral Blood Flow in Man,is. Although the brain represents only 2% of the body mass it has a blood supply of 15% of the resting cardiac output, and utilises nearly a quarter of the body’s total oxygen requirements at rest (Folkow & Neil, 1971). Even small regional changes in flow can result in catastrophic clinical sequelae.

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https://doi.org/10.1007/978-0-387-68805-3through a period of philosophical revision of our understanding of cardiac function and a new consensus is beginning to appear. The essential part of the heart as far as the systemic circulation is concerned is the left ventricle and most attention is directed to the performance of this chamber and its alteration by disease or drugs.

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https://doi.org/10.1007/978-0-387-68805-3is. Although the brain represents only 2% of the body mass it has a blood supply of 15% of the resting cardiac output, and utilises nearly a quarter of the body’s total oxygen requirements at rest (Folkow & Neil, 1971). Even small regional changes in flow can result in catastrophic clinical sequelae.

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https://doi.org/10.1007/978-0-387-68805-3rends in physiology have focused interest on the relationship between RBF and the control of tubular reabsorption. With the introduction of powerful pharmacological agents which affect the resistance to renal blood flow, there has been increasing interest in accurate methods for its measurement.

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https://doi.org/10.1007/978-0-387-68805-3diac cycle. It can be performed non-invasively, so has considerable advantages over cardiac catheterization in that normal subjects can be studied, and repeated measurements made, either in the basal state, or after interventions. It is thus attractive for the study of drugs with an action on the ca

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https://doi.org/10.1007/978-0-387-68805-3astolic pressure. While directional changes over each 24 h period can be defined (Millar Craig, Bishop and Raftery, 1978), no two beats generate exactly the same pressures; beat-to-beat pressure variation appears to be a random process influenced by an almost infinite number of variables (Goldberg,

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