Titlebook: Cardiomyocytes in Health and Disease; Chandrasekharan C. Kartha Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive

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Oleg N. Kirillov,Ferdinand Verhulston. Both gradual and acute cell death via apoptosis, necrosis, and autophagy are hallmarks of HF. Given that the pathophysiology of HF involves death or dysfunction of CMs, understanding their mechanisms is imperative for identifying strategies for the treatment of HF and reducing related complicati

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Cell Cycle Regulation in Cardiomyocytesns of negative cell cycle regulatory genes such as Cdk inhibitors are increased in adult hearts. This article contains a review of the currently known regulatory mechanisms of cell cycle in the cardiomyocyte.

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Cardiomyocyte Senescencelter the phenotype of the endothelial cells, fibroblasts, and immune cells of the heart and thus contribute to pathological remodelling. Non-cardiomyocytes regulate the senescence of cardiomyocyte as well.

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Cardiac Fibroblast and Cardiomyocyte Growthduring development of the heart. How the bidirectional signalling is coordinated during development and promote proliferation of cardiomyocyte progenitors is only partially clear. The indications are that the mechanisms are important for cardiac repair and regeneration.