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Titlebook: Cardiac Safety of Noncardiac Drugs; Practical Guidelines Joel Morganroth (Chief Scientist, Clinical Profess Book 2005 Humana Press 2005 cli

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https://doi.org/10.1007/978-3-030-56707-1ctrocardiogram (ECG) by the QT interval (.,.). Despite a number of limitations associated with its assessment, the drug-induced prolongation of QT interval is considered an important marker for the risk of life-threatening arrhythmias (torsades de pointes [TdP]) (.,.).
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https://doi.org/10.1007/978-3-030-56707-1(TdP), a frequently fatal form of polymorphic ventricular tachycardia. While it is clear that the QT interval on the electrocardiogram (ECG) may not be highly correlated with the risk of TdP, change in the QTc duration is the one relied upon by drug developers and regulatory authorities as the best
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https://doi.org/10.1007/978-3-030-56707-1 cardiac safety assessments throughout phases II and III. Of major concern are drugs which cause the lethal, but rare, ventricular arrhythmia, torsades de pointes (TdP). Indeed, drugs intended for the general population that cause a one in one million incidence of TdP can be a significant public hea
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Conclusion: The Liminal Raconteur,horough” QT studies. The measurement techniques available, the correlation between the RR interval and the QT interval, and the high variability in the QT interval have made the detection of changes in the QT interval difficult, and the verification of a lack of an effect on the QT interval even mor
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https://doi.org/10.1007/978-94-017-2454-8almost always a result of inhibition of the rapid component of the delayed rectifier potassium current (I.). The other current that is infrequently inhibited is its slow component (I.). Drug-induced prolongation of the QTc interval, when excessive in the right setting, can be pro-arrhythmic and dege
发表于 2025-3-24 17:23:50 | 显示全部楼层
https://doi.org/10.1007/978-3-030-56707-1ctrocardiogram (ECG) by the QT interval (.,.). Despite a number of limitations associated with its assessment, the drug-induced prolongation of QT interval is considered an important marker for the risk of life-threatening arrhythmias (torsades de pointes [TdP]) (.,.).
发表于 2025-3-24 21:32:21 | 显示全部楼层
Holter Monitoring for QTctrocardiogram (ECG) by the QT interval (.,.). Despite a number of limitations associated with its assessment, the drug-induced prolongation of QT interval is considered an important marker for the risk of life-threatening arrhythmias (torsades de pointes [TdP]) (.,.).
发表于 2025-3-25 01:35:17 | 显示全部楼层
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