| 书目名称 | Cardiac Glycosides | | 副标题 | Part II: Pharmacokin | | 编辑 | Kurt Greeff (Direktor) | | 视频video | | | 丛书名称 | Handbook of Experimental Pharmacology | | 图书封面 |  | | 描述 | The pharmacokinetics of digitalis glycosides have been the subject of extensive re view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in dicate that the elimination half-life of strophanthin is prolonged in renal failure. | | 出版日期 | Book 1981 | | 关键词 | absorption; kinetics; pharmacokinetics; research | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-68166-0 | | isbn_softcover | 978-3-642-68168-4 | | isbn_ebook | 978-3-642-68166-0Series ISSN 0171-2004 Series E-ISSN 1865-0325 | | issn_series | 0171-2004 | | copyright | Springer-Verlag Berlin Heidelberg 1981 |
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发表于 2025-3-21 19:30:23
