Titlebook: Cardiac Fibrosis and Heart Failure: Cause or Effect?; Ian M.C. Dixon,Jeffrey T. Wigle Book 2015 Springer International Publishing Switzerl

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https://doi.org/10.1007/978-3-319-96941-1lem. Heart failure is the most frequent cause of hospitalization in persons 65 years of age or older and heart failure continues to impose a substantial healthcare burden, despite recent treatment advances. From both an economical and clinical perspective, there is clearly an urgent need for advance

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Francesca Romana Crucinio,Roberto Fontana in the heart including the synthesis and remodeling of the extracellular matrix (ECM), which is the component of the heart that includes interstitial collagens. In the setting of heart disease, including heart failure (HF), abnormal fibroblast proliferation and deposition of collagens leads to adve

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Ian M.C. Dixon,Jeffrey T. WigleFocuses on autophagy and endoplasmic reticular stress as mechanisms to regulate cardiac fibrosis.Highlights the role of alterations in the extracellular matrix during the development of heart failure.

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Homegeneity Testing for Covariance Matrices, the current state of investigation to address the biology of cardiovascular fibroblasts, valvular interstitial cells (VICs), and myofibroblasts is warranted. This book will help to adapt the information that we have gathered in order to translate it into treatments for fibrotic cardiac diseases and thus alter the course of their progression.