| 书目名称 | Cardiac Fibrosis and Heart Failure: Cause or Effect? |
| 编辑 | Ian M.C. Dixon,Jeffrey T. Wigle |
| 视频video | |
| 概述 | Focuses on autophagy and endoplasmic reticular stress as mechanisms to regulate cardiac fibrosis.Highlights the role of alterations in the extracellular matrix during the development of heart failure. |
| 丛书名称 | Advances in Biochemistry in Health and Disease |
| 图书封面 |  |
| 描述 | .The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated. Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood. This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM. The book showcases chapters that highlight discussion of role of Transforming Growth Factor β (TGFβ), an important fibrogenic cytokine and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented..The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood. In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on o |
| 出版日期 | Book 2015 |
| 关键词 | Cardiac Fibrosis; Myofibroblasts; cardiac extracellular matrix; cardiac fibroblasts; microRNAs |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-17437-2 |
| isbn_softcover | 978-3-319-37995-1 |
| isbn_ebook | 978-3-319-17437-2Series ISSN 2512-2142 Series E-ISSN 2512-2150 |
| issn_series | 2512-2142 |
| copyright | Springer International Publishing Switzerland 2015 |
发表于 2025-3-21 19:00:45
