Titlebook: Cardiac Adaptation in Heart Failure; Risks due to myocard J. Holtz,H. Drexler,H. Just Conference proceedings 1992 Dr. Dietrich Steinkopff V

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贝雷帽

Signaling mechanisms for the activation of an embryonic gene program during the hypertrophy of cardponse. The induction of the atrial natriuretic factor gene (ANF) is one of the most conserved features of ventricular hypertrophy, occurring in multiple species (mouse, rat, hamster, canine, and human) in response to diverse stimuli (hormonal, mechanical, pressure/volume overload, genetic, IHSS, hyp

CT-angiography

Endothelial modulation of myocardial contraction: mechanisms and potential relevance in cardiac disrdial contractile behaviour and cardiac pump function in a novel manner, mainly by influencing the duration of contraction and the onset of relaxation but without major effect on early systolic contractile characteristics. These effects are mediated by the release of at least two diffusible substanc

商谈

The regulation of calcium cycling in stressed hearts,t which it is removed in control, thyrotoxic and pressure-overloaded rabbit hearts. Experiments were carried out at 30°C. In control rabbit hearts 41.0 ± 7.0 nmoles/g Ca. was released into the cytosol for each beat, while the rate at which the Ca. was removed from the cytosol was 24.4 ± 4.4 nmoles/g

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Energetics of calcium cycling in nonfailing and failing human myocardium,ling dilated cardio-myopathic hearts at a stimulation rate of 60 beats per minute (37°C). This frequency was chosen because analysis of the force-frequency relation showed significant differences in isometric force between failing and nonfailing human myocardium at 60 beats per minute and at higher

Cardiac

Spontaneous sarcoplasmic reticulum Ca2+ release leads to heterogeneity of contractile and electricaly within and among cells. The SR can also generate spontaneous Ca. oscillations (S-CaOs), i.e., not triggered by sarcolemmal depolarization. The local increase in Ca. due to S-CaOs is equivalent to that induced by an AP. Heterogeneity of diastolic Ca. caused by asynchronous S-CaOs among cells withi

RLS898

Afterdepolarizations and triggered activity,on. The delayed afterdepolarization (DAD) arises from the resting potential after full repolarization of an action potential and it may reach threshold for activation. It is favored by cellular Ca overload, and rapid preceding activation rates. The inward current generating the DAD is caused by one

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The contribution of nonreentrant mechanisms to malignant ventricular arrhythmias,trant mechanisms also appear to be operative under a wide variety of pathophysiologic conditions. For example, results obtained using three-dimensional (3D) mapping from 232 simultaneous sites in the feline heart in vivo revealed that nonreentrant or focal mechanisms were prominent during both ische

赔偿

The potential role of Ca2+ for electrical cell-to-cell uncoupling and conduction block in myocardiaee [Ca.].. It is well documented that elevated [Ca.]. may produce SR release of Ca. and oscillations of membrane potential, thereby leading to triggered or spontaneous ectopic activity. The relation among elevated free [Ca.]., electrical cell-to-cell coupling, conduction slowing, and reentrant arrhy

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