Titlebook: Carcinogenicity; The Design, Analysis Harold C. Grice,Joseph L. Ciminera Book 1988Latest edition Springer-Verlag New York Inc. 1988 cancer.

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https://doi.org/10.1007/978-3-662-00754-9nd/or activated metabolites may not be directly proportional to the administered dose. Instead, disproportionate increases or decreases may be observed with concurrent effects upon toxicity. Levy (1968) described some of the criteria that suggest that such saturation may be occurring:

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Integration of Pharmacokinetics and Pathological Data in Dose Selection for Chronic Bioassaysnd/or activated metabolites may not be directly proportional to the administered dose. Instead, disproportionate increases or decreases may be observed with concurrent effects upon toxicity. Levy (1968) described some of the criteria that suggest that such saturation may be occurring:

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Factors Affecting Histopathologic Interpretation of Toxicity—Carcinogenicity Studiesic evaluation is the responsibility of the pathologist. To understand the data generated by the pathologist, it is necessary to have a general understanding of pathology and to be aware of some of the factors which can affect the histopathologic interpretation of toxicity-carcinogenicity studies.

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Business Cycles: Discrete Space, tumors (and, if so, of what type), or is the objective the very practical need to reveal a carcinogenic hazard under particular experimental circumstances and to extrapolate to the risk of that action in a different target species under other conditions?