Titlebook: Carcinogenesis: Fundamental Mechanisms and Environmental Effects; Proceedings of the T Bernard Pullman,Paul O. P. Ts’o,Harry Gelboin Confer

Debark

Immunological Detection and Quantification of DNA Components Structurally Modified by Alkylating Cale to eliminate from their DNA the O.-ethyl- dGuo produced by EtNU. To facilitate quantification of alkylation products at low concentrations in the DNA of small amounts of tissues and cells, we have, as a first step, developed high-affinity “conventional” and monoclonal antibodies specifically dire

Dappled

adumbrate

–吃

Dihydrodiols and Diol-Epoxides in the Activation and Detoxification of Polycyclic Hydrocarbons,ter embryo cells treated with the hydrocarbon contain adducts arising from the reactions with the nucleic acid of both the ‘bay- region’ .-3,4-diol-1,2-epoxide and the non-‘bay-region’ .-8,9- diol-10,11-epoxide. However, only the 8,9-diol-10,11-epoxide appears to be involved in the reaction of the h

锯齿状

Metabolically Generated Free Radicals from Many Types of Chemical Carcinogens and Binding of the Raderivatives, acetylaminofluorene and naphthylamines have been found to be easily converted to free radicals after being activated to the proximate forms. These free radicals were sufficiently reactive to bind covalently with nucleic acid bases. Anthanthrene which lacks bay region and 10-aza-benzo[a)

Gnrh670

Nucleophilicity of DNA. Relation to Chemical Carcinogenesis.,re .: positive ions or uncharged molecules with reactive centers at their electron deficient atoms (see e.g. 1,2). This is true both for carcinogens considered as being active . (a number of relatively simple alkylating agents) and those which necessitate a metabolic activation (aromatic hydrocarbon