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Titlebook: Capsaicin as a Therapeutic Molecule; Omar M. E. Abdel-Salam Book 2014 Springer Basel 2014 analgesic substance.capsaicin.resiniferatoxin.va

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Nitrogen Fixation with Non-Legumesd the door for the drug industry to introduce a new chapter of analgesics. After several lines of translational efforts with over 1,000 patents and clinical trials, the 8 % capsaicin dermal patch reached the market and its long-lasting local analgesic effect in some severe neuropathic pain states is
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Nitrogen Fixation with Non-Legumes sub-set of primary sensory neurons which responds to various stimuli including noxious heat (>~42 °C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers. Subsequently, TRPV1 has been found indispensable for the development of burning pain and reflex hyperactivity associ
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C. Forni,M. Grilli Caiola,S. Gentili—capsaicin, for the treatment of peripheral neuropathic pain. Given the limitations of current oral and parenteral therapies for the management of pain arising from various forms of nerve injury, alternate therapeutic approaches that are not associated with systemic adverse events that limit quality
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Nitrogen Fixation with Non-LegumesV1 antagonism has so far shown limited benefit in antinociception. Capsaicin, a TRPV1 agonist, has been shown to induce a refractory period in the nerve terminal expressing TRPV1 and even, in sufficient dosing, to create long-term nerve terminal defunctionalization. This has led to research into top
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