Titlebook: Cannabinoids and Sleep; Molecular, Functiona Jaime M. Monti,S. R. Pandi-Perumal,Eric Murillo-Ro Book 2021 The Editor(s) (if applicable) and

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https://doi.org/10.1007/978-3-031-34721-4lated by specialized brain structures that, by means of different neurotransmitters, maintain the constant expression of the sleep-wake cycle. Molecules like orexin, serotonin, noradrenaline, histamine, for waking; GABA, adenosine, prostaglandins, for NREM sleep and acetylcholine and glutamate for R

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Vira Shendryk,Reza Malekian,Paul Davidsson wide variety of biological processes. In this chapter, the studies detailing the effects of cannabinoids on sleep in laboratory animals are reviewed. Both exogenous and endogenous cannabinoids generally appear to decrease wakefulness and alter rapid eye movement (REM) and non-REM sleep in animal mo

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https://doi.org/10.1007/978-3-031-31066-9ese brain areas, located in the brainstem, play a pivotal role in the control of various functions and behaviors that are altered by cannabinoids (i.e., pain, arousal, mood, anxiety, or sleep-wake cycle). Anatomical, neurochemical, and functional data suggest that cannabinoids regulate both central

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https://doi.org/10.1007/978-3-031-31066-9d molecular systems exerts influences in the modulation of the sleep-wake cycle. Moreover, homeostatic and circadian mechanisms interact to control the waking or sleeping states. As many other behaviors, sleep also develops pathological features that include several signs and symptoms corresponding

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Lecture Notes in Networks and Systemsct these routines by regulating neuronal firing within the suprachiasmatic nucleus, the master circadian pacemaker in the brain. These actions of cannabinoids on the brain’s clock may also underlie time-wraps commonly experienced by marijuana users.

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Lecture Notes in Networks and Systemsntly reemerged and became more accessible. Cannabis is usually employed as a self-medication for the treatment of insomnia disorder. However, the effects of Cannabis on sleep depend on multiple factors such as metabolomic composition of the plant, dosage and route of administration. In the present c

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978-3-030-61665-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl