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Titlebook: Cancer, Complexity, Computation; Igor Balaz,Andrew Adamatzky Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive li

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,Pinning Control to Regulate Cellular Response in Cancer for the p53-Mdm2 Genetic Regulatory Networkduced to induce an increased expression of p53 levels and downregulation of Mdm2 and p53 activation using only three controlled states (pinned nodes) of the network for the first case and two states for the second case, respectively. The analytic results are simulated, which illustrate the feasibility of the proposed control scheme.
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A Haploid-Diploid Evolutionary Algorithm Optimizing Nanoparticle Based Cancer Treatments, shown that varying fitness landscape ruggedness varies the benefit of haploid-diploid algorithms. Moreover, the methodology is applied to optimise the targeted delivery of a therapeutic compound utilizing nano-particles to cancerous tumour cells with the multicellular simulator PhysiCell.
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https://doi.org/10.1007/978-3-319-38915-8duced to induce an increased expression of p53 levels and downregulation of Mdm2 and p53 activation using only three controlled states (pinned nodes) of the network for the first case and two states for the second case, respectively. The analytic results are simulated, which illustrate the feasibility of the proposed control scheme.
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2194-7287 biologists, and mathematicians.Presents attractive reading f.This book presents unique compendium of groundbreaking ideas where scientists from many different backgrounds are united in their interest in interdisciplinary approaches towards origins and development of cancers, innovative ways of searc
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,Modeling Tumour Growth with a Modulated Game of Life Cellular Automaton Under Global Coupling, only two free parameters. Parameter . governs the strength of a global coupling of the cells due to the confinement pressure. Parameter . governs the strength of the intercellular coupling which modulates the local dynamic rules of Conway’s Game of Life.
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