Titlebook: Cancer in Children; Clinical Management P. A. Voûte,Ann Barrett,Jean Lemerle Book 1992Latest edition Springer-Verlag Berlin Heidelberg 1992

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Malignant B-Cell Lymphoma of Childhoodrences of practical relevance. In this chapter we consider separately (a) the sporadic BCL observed in Europe and North America, whether or not it is categorized histologically as Burkitt’s lymphoma, excluding large-cell lymphoma, and (b) the typical well-defined endemic Burkitt’s lymphoma which is commonly found in some African areas.

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Delayed Consequences of Therapyesigned clinical studies that assess the probability of new toxicities whose full expression emerges only over a long period of observation. The former requires that attention be paid to individual patients, their previous disease and treatment, while the latter requires that standardized evaluation

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overview.The pediatric oncologist can easily bring his knowledge ofthe field up to date with this book; the pediatricianandgeneral practitioner will discover the quick source ofinformationhe needs on this specialized topic. A gem forevery physicians!978-3-642-84724-0978-3-642-84722-6

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Trevor M. Hopper,Anthony J. Berry mononuclear phagocytic system. The dendritic cell line is intimately involved with the thymus-dependent regions of the body. These cells are powerful stimulators of mixed lymphocyte response. Each disorder in the histiocytosis syndromes is viewed as resulting from a reactive or neoplastic prolifera

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Aetiology and Epidemiologyf highly specialized institutions treat most childhood cancer types, so that some estimates of occurrence, although subject to selection bias, can be made from their files. In addition, given the rarity of childhood cancers, associations relevant to aetiology have been identified through small serie

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Oncogenes and Chromosomal Aberrationshia chromosome, or Ph., was consistently found in leukaemic cells of patients with chronic myeloid leukaemia (CML). In the past 15 years the use of advanced cytogenetic techniques in studying various tumours has led to the conclusion that most cancers involve a chromosomal defect, often specific and

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Principles of Cancer Chemotherapy in Childrense diseases. The antineoplastic drugs currently used in clinical practice exert their cytotoxic effect by interfering with the synthesis or function of DNA. Figure 1 indicates schematically the site of action of commonly used anticancer drugs in paediatric oncology. Most of these drugs are cell-cycl