Titlebook: Cancer Therapeutic Targets; John L. Marshall Reference work 2017 Springer Science+Business Media New York 2017 Anti-angiogenic Targets.HER

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Anti-B7-H47-H4 up-regulation has shown to be associated with diseases progression and/or outcome in some cancers. The unique expression of B7-H4 in the tumor microenvironment and its potential immune inhibitory functions on both innate and adaptive immune responses represents a novel target for the next-generation cancer diagnosis and immunotherapy.

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B7.1s, which play a central role in mediating tumor immunosurveillance and immune-mediated tumor regression (Ward and Kaufman, Int Rev Immunol 26:161–196, 2007). B7-1 consequently plays an important role in cancer vaccines that focus on harnessing the potential of the host immune system to recognize and eradicate malignant tumors.

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Bacterial Vaccinesdifications that attenuate their pathogenicity but strengthen anti-tumor potential and the desirable mechanisms of actions. The only FDA approved .-based cancer therapy as well as numerous examples of ongoing clinical trials involving different bacterial strains are presented.

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CCL21. Based on the findings on CCL21, it is anticipated that rational combinations with other treatment modalities will improve the therapeutic efficacy of this chemokine and antitumor benefit in a broad range of solid tumors.

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Dendritic Cellsl Prize in 2011. These cells play a vital role in our immune system, covering both innate and adaptive immune responses, and come from a variety of lineages and have various locations (Kuby et al., Immunology, 6th edn. W.H. Freeman, New York, 2007).

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Herbert Oertel jr.,Eckart Lauriene other members of the tumor necrosis factor superfamily, the ecto-domain of 4-1BB forms a homotrimer with an extended, three-bladed propeller structure (Won et al. 2010). 4-1BB also has a cysteine-rich extracellular domain, a transmembrane region, and a cytoplasmic domain that contains a tyrosine kinase p56. binding site (Vinay and Kwon 2006).

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