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Titlebook: Cancer Systems Biology, Bioinformatics and Medicine; Research and Clinica Alfredo Cesario,Frederick Marcus Book 2011 The Editor(s) (if appl

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System Dynamics at the Physiological and Tumour Level spatial heterogeneity. This variability, while critical to the ability of cancers to adapt to a wide range of environmental perturbations including therapy, tends to be lost in molecular-level data which is typically an ‘average’ value for large numbers of heterogeneous tumour cells obtained at a s
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Circadian Rhythms and Cancer Chronotherapeuticscellular clocks are coordinated by a hypothalamic pacemaker, the suprachiasmatic nuclei, which generate or control circadian physiology. The CTS down-regulates malignant growth in experimental models and in cancer patients. It also generates large and predictable 24-h changes in toxicity and efficac
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https://doi.org/10.1057/9780230591509f knowledge and decisions; organize information in more accessible and applicable ways; extend understanding of complicated biological interactions; and provide numerical test beds for planning and implementing biomarker and drug development and treatment strategies.
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https://doi.org/10.1007/978-1-349-26622-7marker effective discovery and prioritisation..Finally, we emphasize the need for large-scale harmonization, standardization and integration of multi-level data to ensure that the potential offered by the current unprecedented availability of data and information is fully exploited, so as to develop validated and useful biomarkers.
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Diagnostic and Prognostic Cancer Biomarkers: From Traditional to Systems Approachesmarker effective discovery and prioritisation..Finally, we emphasize the need for large-scale harmonization, standardization and integration of multi-level data to ensure that the potential offered by the current unprecedented availability of data and information is fully exploited, so as to develop validated and useful biomarkers.
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Introduction to Systems Approaches to Cancerf knowledge and decisions; organize information in more accessible and applicable ways; extend understanding of complicated biological interactions; and provide numerical test beds for planning and implementing biomarker and drug development and treatment strategies.
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