Titlebook: Cancer Stem Cells: Basic Concept and Therapeutic Implications; Farhadul Islam,Alfred K. Lam Book 2023 The Editor(s) (if applicable) and Th

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Origin and Development of Cancer Stem Cells,naling pathways, the tumor microenvironment, and the embryonal rest theory. This current chapter introduces CSCs research history and provides an overview of the current theories regarding origin and development of CSCs.

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The Genetic and Epigenetic Landscape of Cancer Stem Cells,argeting the epigenetic mechanisms which give CSCs the ability to persist through cancer treatment. Epigenetic targeting dugs show promising clinical trial results as they combat the resistant nature of CSCs due to their frequent epigenetic changes.

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Cancer Stem Cells in Cancer Initiation and Progression,ncer, as it is difficult to eliminate CSCs and prevent the spread of the disease. There is ongoing research into the molecular and cellular mechanisms underlying the properties of CSCs, as well as efforts to develop targeted therapies that specifically target CSCs to improve the treatment of cancer.

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Cancer Stem Cells and Metastasis,o-mesenchymal transition (EMT), pre-metastatic niche, metastatic niche, mesenchymal-to-epithelial transition (MET), angiogenesis, and dormancy in relation to metastasis. This chapter also explores potential molecular markers that could increase the metastatic potential of CSCs in common cancers, inc

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Cancer Stem Cell Therapeutic Delivery and EPR Effect,es to overcome this problem. Briefly, due to the unique characteristics of tumor vasculature, nanomedicines selectively accumulate in tumor tissue avoiding normal tissues, resulting in negligible side effects and exhibit profound tumor selectivity. However, challenges do exist in the development of

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Diagnostic and Prognostic Significance of Intracellular Markers of CSCs in Patients with Cancers,n of Oct-3/4 expression is correlated with neoplastic transformation and therapy resistance in patients with various cancers. In CRC, for instance, an increase of Oct-3/4 is associated with migration, liver metastasis, and poor survival. In addition, higher expression of Oct-3/4 in CSCs is associate

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