| 书目名称 | Cancer Immunology and Immunotherapy | | 编辑 | Glenn Dranoff | | 视频video | | | 概述 | The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers an | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment. | | 出版日期 | Book 2011 | | 关键词 | dendritic cells; immune infiltration; regulatory T cells; signal transducer and activator of transcript | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-14136-2 | | isbn_softcover | 978-3-642-26788-8 | | isbn_ebook | 978-3-642-14136-2Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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发表于 2025-3-21 19:06:12
