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Titlebook: Cancer Immunology; R. Adrian Robins,Robert C. Rees Book 2001 Springer Science+Business Media Dordrecht 2001 Antigen.immunotherapy.melanoma

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The immune response to oncogenic fusion proteins,e consequence of chromosomal translocation is the creation of a new fusion gene encoding for a chimeric protein. It is well established that these proteins are necessary and sufficient for the malignant transformation of normal cells [1, 2]. Chromosomal translocations coding for oncogenic fusion pro
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Immunological significance of hsp70 in tumor rejection,under the selective pressure of infectious agents. To the contrary, tumors that arise generally after the age of reproduction should have no major influence on the evolution of the immune system. Nevertheless, animal and human tumors can sometimes be rejected spontaneously by the immune system of th
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Genetically modified tumour cells for cancer immunization,respond to the tumour antigens intervention is required. This can be achieved by transfection of the tumour cells with genes encoding a variety of immunostimulatory molecules. The most obvious approach is the transduction of tumour cells taken from the body with genes that encode molecules (such as
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Escape Mechanisms in Tumour Immunity,tem. This has been shown not only in experimental animals but also for spontaneously arising human tumours. Tumour progression may therefore require the evolution of variants which can “escape” the immune response. Mechanisms for the escape of tumours from immune responses (endogenous or therapeutic
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Data Mining Techniques in Clustering, Association and Classification,ries, management insisted their information officers develop methodology to exploit the knowledge held in their repositories. The process of extracting this knowledge evolved as an interdisciplinary field of computer science within academia. This included study into statistics, database management a
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