Titlebook: Cancer Drug Delivery Systems Based on the Tumor Microenvironment; Yasuhiro Matsumura,David Tarin Book 2019 Springer Japan KK, part of Spri

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https://doi.org/10.1007/978-3-662-63294-9enable the encapsulated drugs or imaging agents to be delivered to specific sites for the treatment and diagnosis, respectively, of refractory diseases such as cancer. In this chapter, the advantages of the use of active-targeting liposomes as a tool of DDS and their application to cancer treatment are reviewed.

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The Cancer Stroma and Its Relevance to Tumor Survival and Treatment, incurred during tumorigenesis, cause unpredictable evolution in the collective properties of the whole community. This chapter provides pathologic observations and data on reciprocal interactions between these stromal and neoplastic cellular components of tumors and how they change during the cour

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Cancer and Blood Coagulation unique properties of the mAb, it is not neutralized by soluble fibrinogen or soluble fibrin products in the body. Our anti-fibrin clot mAb recognizes an unexplored pocket that is only uncovered when a fibrin clot forms. The epitope in the pocket is a hydrophobic region on the Bβ-chain that interact

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Tumor Blood Vessels as Targets for Cancer Therapyy by tumor microenvironmental factors. Furthermore, TECs induce cancer progression through metastasis passively but also actively. This chapter will review the mechanisms underlying tumor angiogenesis and discuss the biology of TECs, offering new perspectives on treatment strategies that can target

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IVORY

Preclinical Studies of ADC Therapy for Solid Tumorsof the drug. The linkers are categorized into cleavable and non-cleavable linkers and serve to bind the drug payload to the antibody. Using this strategy the payloads can achieve 100–1000 fold higher cytotoxic potency than conventional anti-cancer agents because comparable therapeutic effects can be

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Kinetic

CAST Therapyal tumor environment..However, none of them has been proved to be effective in treating refractory cancers such as pancreatic cancer or scirrhous gastric cancer. These cancers are known to possess abundant stroma, which hinders the distribution of therapeutic antibodies and ADCs within the cancerous

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