Titlebook: Cancer Diagnostics; Current and Future T Robert M. Nakamura,Wayne W. Grody,Raymond B. Nagle Book 2004 Springer Science+Business Media New Y

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Molecular Diagnostics in Neoplastic Hematopathologyecame a defining feature in the evaluation of patients with chronic myeloproliferative disorders. The discovery of rearrangements of immunoglobulin genes in lymphocytes and their use as clonal markers in lymphoid proliferations introduced the molecular genetic tool of Southern blot analysis to lymphoma diagnosis ..

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Zusammenfassung und Schlusswort,tion and software, availability of high quality fluoro chromes and monoclonal antibodies, improved gating strategies, routine use of multiparam eter approaches, and increased emphasis on clinicopathologic correlations.

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Identification of Risk Factors for Early Neoplasmis. It is well known that during the phagocytosis of bacteria or virus-infected cells, a powerful mixture of oxidants such as nitric oxide (NO), O. and H.O. are released. These oxidants from infection may cause oxidative damage to DNA, leading to mutations and eventually carcinogenesis ..

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Emerging Circulating Tumor Markerst appear to have improved clinical utilities. In addition, a new group of circulating tumor markers are also described in this chapter relating to the signal transduction pathway, cell cycle, apoptosis, angiogenesis, and adhesion. This addition is largely owing to the recent change of emphasis on tu

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Prostate Cancer Markerson of a marker is an important factor to consider when assessing the potential of new markers. Table 2 and Fig. 1 illustrate PCa markers catagorized by biological activity. What are the clinical utilities and deficiencies for PSA today and what are the features of PAP and PSA, which contribute to th

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Study of Sentinel Lymph Nodes in the Staging of Malignant Neoplasmsn humans employed radioactive colloid gold ., and later the less active technetium99 (TC-99) came into use .. Peritumoral injections of radiocolloid are now used in sentinel node biopsy to visualize draining nodes preoperatively by lymphoscintigraphy and intraoperatively using a handheld Geiger coun

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