Titlebook: Camptothecins in Cancer Therapy; Val R. Adams,Thomas G. Burke Book 2005 Humana Press 2005 DNA.biochemistry.brain.brain tumors.cancer.cance

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Progress in Inflammation Researchon. The parent compound, CPT, was extracted from the leaves of . by Wall and Wani in 1957. The hydrophilic carboxylate salt entered clinical trials in the late 1960s. The lack of efficacy and unpredictable bone marrow and bladder toxicity halted its clinical development (.). When topoisomerase I (TO

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Progress in Inflammation Researchagnosed in the United States, and an estimated 157,200 deaths occurred from the disease. The incidence rate of lung cancer is declining in men, from a high of 102.1 per 100,000 in 1984 to 81.1 per 100,000 in 1999. In the late 1990s the incidence of lung cancer seen in women, which had been steadily

Odyssey

Brain Atlases and Neuroanatomic Imaginged (.–.). This is particularly true for the elderly, who account for the majority of cases of acute myelogenous leukemia (AML) (.,.). Because of unrelated medical problems, as well as a higher incidence of certain resistance mechanisms (e.g., overexpression of the mdr1 multidrug transporter), eradic

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Val R. Adams,Thomas G. BurkeIncludes supplementary material:

NAUT

Cancer Drug Discovery and Developmenthttp://image.papertrans.cn/c/image/220974.jpg

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Camptothecins in Cancer Therapy978-1-59259-866-3Series ISSN 2196-9906 Series E-ISSN 2196-9914

anaerobic

Mechanism of Action of Topoisomerase 1 Poisonsndensation, and segregation (.–.). They perform their topological transformation reactions on DNA via a concerted breakage/religation mechanism (.,.–.). Because of their delicate act on DNA, topoisomerases can be double-edged swords. It is now well established that many xenobiotics, DNA lesions, and