Titlebook: Camptothecins in Cancer Therapy; Val R. Adams,Thomas G. Burke Book 2005 Humana Press 2005 DNA.biochemistry.brain.brain tumors.cancer.cance

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The Role of Apoptosis in Neuroinflammation,ls that are actively replicating DNA (.,.,.). Because of their proliferating nature, cancerous cells spend more time in the S-phase relative to normal cells. Also, it has been shown that TOP-I is overexpressed in a variety of tumor lines (.,.). Logically, the accelerated rate of cell replication and

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Crystallographic Insight Into the Mechanism of Drug-Induced Topoisomerase I DNA Damageication reaction (.). The rate of relegation is normally much faster than is the rate of cleavage (.). This ensures that the steady state concentration of the covalent 3′-phosphotyrosyl TOP-I-DNA complex is extremely low. Several DNA lesions and drugs, however, have been shown to stabilize the coval

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Clinical Experience With Topotecanous (iv) infusion of 1.5 mg/m. daily for 5 days, which is repeated every 3 weeks. Topotecan is available as a parenteral preparation and is supplied in vials containing 4 mg, which is reconstituted in 4 mL sterile water. The resulting 1 mg/mL solution is further diluted with a 5% dextrose or 0.9% sa

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