| 书目名称 | Calcium and Ion Channel Modulation | | 编辑 | Alan D. Grinnell,David Armstrong,Meyer B. Jackson | | 视频video | | | 图书封面 |  | | 描述 | Cellular neurobiology has been transformed in the past decade by new technologies and fundamental discoveries. One result is an enormous increase in our understanding of how ion channels function in nerve and muscle cells and a widening perspective on the role of ion channels in non-neuronal cell physiology and development. Patch clamp techniques now permit direct observation of the transitions between functional confor mations of individual ion channels in their native membrane. Recombinant DNA techniques are being used to determine the primary structure of ion channel proteins and to test hypotheses about channel conformations, sites of grating and modulation, and the basis of ion selectivity. At the same time, biochemical techniques have revealed intricate signalling systems in side cells, involving second messengers such as calcium, phospholipids and cyclic nucleotides, which interface with the external milieu through GTP binding proteins and regulate cell metabolism by altering protein phos phorylation. This panorama of second messenger systems has greatly increas ed our application for their potential role in regulating ion channel function. We now recognize that ion chan | | 出版日期 | Book 1988 | | 关键词 | DNA; activation; biology; cell; cell physiology; escherichia coli; growth; membrane; metabolism; neurobiology | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4613-0975-8 | | isbn_softcover | 978-1-4612-8273-0 | | isbn_ebook | 978-1-4613-0975-8 | | copyright | Plenum Press, New York 1988 |
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发表于 2025-3-21 18:36:19
