Titlebook: Calcium Binding Proteins in Normal and Transformed Cells; Roland Pochet,D. Eric M. Lawson,Claus W. Heizmann Book 1990 The Editor(s) (if ap

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Functional Analysis of the Promoter Region of the Gene Encoding Chicken Calbindin D28K986), matrix Gla protein (Fraser et al., 1988), parathyroid hormone (Okazaki et al., 1988), c myc (Simpson et al., 1987), and a family of calcium-binding proteins termed calbindins. At least two types of calbindins exist: a M 9,000 protein (Calbindin D9K), present in mammalian intestine (Kallfelz et

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Calbindin-D9K (CaBP9K) Gene: A Model for Studying the Genomic Actions of Cacitriol and Calcium in Macovered by Wasserman’s group in 1967 (2). This acidic protein has 2 calcium-binding sites organized as “EF-hands” (3, 4). CaBP9K was first located in the absorptive cells of the duodenum but is also found in the epithelial cells of the placenta and uterus, as demonstrated by in situ hybridization (5

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Mutant Analysis Approaches to Understanding Calcium Signal Transduction Through Calmodulin and Calmo example, the occupancy of a cell surface receptor by a drug, hormone or a growth/differentiation factor often results, directly or indirectly, in a rise in the intracellular concentration of ionized calcium. This transient, localized rise in calcium sets off a discrete set of cellular responses. Th

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Structure of the Calcium Release Channel of Skeletal Muscle Sarcoplasmic Reticulum and Its Regulationates at the neuromuscular synapse and spreads rapidly into the transverse tubule (T-) system of membrane infoldings, which extend inward from the surface membrane to surround each myofibril. In an incompletely understood process termed excitation-contraction coupling (Somlyo, 1985), T-system depola

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Structural and Functional Investigation of p68 - A Protein of the Lipocortin/Calpactin Familyatories, and invited wide-ranging hypotheses regarding their physiological functions (Crompton et al., 1988b, Klee 1988). The first proposals for the functions of two of these proteins were based on their apparent inducibility by glucocorticoids (as regulators of phos-pholipase A2 activity in inflam

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Structure-Function Relations in Troponin C. Chemical Modification StudiesC transmitted to other components of the thin filament result in triggering of muscle contraction (for review see Leavis and Gergely 1984; Zot and Potter 1987). The 3-D crystal structure of TnC isolated from turkey and chicken skeletal muscle has been solved and refined recently at better than 0.2 n