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Titlebook: Calcium Antagonists; A Critical Review Helmut Lydtin,Peter Trenkwalder Book 1990 Springer-Verlag Berlin Heidelberg 1990 Parkinson.anesthesi

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Chemical Structure and Pharmacokinetics of Calcium Antagonists,ärtfelder 1962). The basic chemical structures of verapamil and subsequent derivatives are shown in Fig. 7. In contrast to the 3,4-dimethoxy substitution of verapamil, the successor compound gallopamil (D 600) shows a 3,4,5-trimethoxy substitution on the benzene ring. Both substances are optically a
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Pharmacological Effects of Calcium Antagonists,pressure compartment (Fig. 10). The high-pressure compartment embraces the left ventricle in systole and the arterial vascular system as far as the capillary bed. The postcapillary venules, veins, right side of the heart, pulmonary circulation and left atrium (and in diastole the left ventricle) for
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Indications for Calcium Antagonists,s, and they are now also widely used in other forms of coronary heart disease. Although their antihypertensive action was first described as long ago as the early 1960s, it is only in the last few years that calcium antagonists have established themselves worldwide in the treatment of hypertension.
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,Side Effects — Overdosage — Contraindications — Drug Interactions,xperience side effects (Table 31), the latter are frequently only minor and recede during the course of treatment. Severe side effects which lead to discontinuation of calcium antagonist therapy are relatively rare, the incidence stated in the literature lying between 1% and 5%, depending on the sub
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https://doi.org/10.1007/978-3-662-25277-2partment by a factor of 100–200. For this reason, the low-pressure compartment is especially well equipped to accommodate variations in volume without significant changes in mean pressure levels. Regulation of blood pressure predominantly takes place through arterial receptors in the high-pressure c
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Pharmacological Effects of Calcium Antagonists,partment by a factor of 100–200. For this reason, the low-pressure compartment is especially well equipped to accommodate variations in volume without significant changes in mean pressure levels. Regulation of blood pressure predominantly takes place through arterial receptors in the high-pressure c
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