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Titlebook: Brain Glycogen Metabolism; Mauro DiNuzzo,Arne Schousboe Book 2019 Springer Nature Switzerland AG 2019 glycogen synthase.phosphorylase.ion

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发表于 2025-3-21 17:23:50 | 显示全部楼层 |阅读模式
期刊全称Brain Glycogen Metabolism
影响因子2023Mauro DiNuzzo,Arne Schousboe
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发行地址Provides a timely and extensive overview of current knowledge of cerebral glycogen aimed at fundamentally revisiting the vestigial nature commonly associated with this polysaccharide in the brain.Focu
学科分类Advances in Neurobiology
图书封面Titlebook: Brain Glycogen Metabolism;  Mauro DiNuzzo,Arne Schousboe Book 2019 Springer Nature Switzerland AG 2019 glycogen synthase.phosphorylase.ion
影响因子.This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.  .
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Technical and Comparative Aspects of Brain Glycogen Metabolism,n. This uncertainty stems in part from several technical challenges inherent in the study of brain glycogen metabolism, and may also stem from some conceptual limitations. Factors presenting technical challenges include low glycogen content in brain, non-homogenous labeling of glycogen by radiotrace
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Glycogenolysis in Cerebral Cortex During Sensory Stimulation, Acute Hypoglycemia, and Exercise: Impd memory consolidation, is strongly supported by many studies. However, specific mechanisms through which glycogen sustains essential functions remain to be established by rigorous, quantitative studies. Cerebral cortical glycogen concentrations are in the range of 10–12 μmol/g in carefully-handled
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State-Dependent Changes in Brain Glycogen Metabolism,. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe
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Glycogen in Astrocytes and Neurons: Physiological and Pathological Aspects, in brain function. In this regard, genetically modified animals have allowed researchers to unravel new roles of this polysaccharide in the brain. Remarkably, mice in which glycogen synthase is abolished in the brain, and thus devoid of brain glycogen, are viable, thereby indicating that the polysa
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