Titlebook: Brain Chemistry and Mental Disease; Proceedings of a Sym Beng T. Ho,William M. McIsaac Conference proceedings 1971 Springer Science+Busines

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Studies on the Mechanism of Action of 6-Methoxytetrahydro-β-Carboline in Elevating Brain SerotoninGlassman (1969). If resolution of the problem as to the function of these amines lies in the differential elevation of a specific amine, then it would seem desirable to have an agent that would specifically elevate only one brain amine.

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Multiple Forms of Monoamine Oxidase in Developing Tissues: The Implications for Mental Disorder966; Eberle and Eiduson 1968). More specifically, we believe as others do that a knowledge of how the biosynthesis, tissue levels, and catabolism of these amines are regulated during brain development may lead to a greater understanding of the biochemical and behavioral individuality exhibited by hi

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Behavioral, Metabolic, and Enzymatic Studies of a Brain Indoleethylamine N-Methylating Systemlation hypothesis of schizophrenia (Osmond and Smythies 1952) and Axelrod’s exciting and systematic elucidation of various amine-methylating enzymes in the central nervous system (Axelrod 1965), our own particular interests in this field started in 1964 when we were studying the effect of the intrav

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Pharmacological Implications of the Effects of Amphetamine and Its Analogs on the Turnover Rate of TBell (1965), and Kety (1967) have proposed this psychosis as a model for the study of affective disorders and schizophrenia. A better understanding of the biochemical factors involved in the actions elicited by .-amphetamine may increase the practical utility of this model. The picture that has emer

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Studies on the Mechanism of Action of 6-Methoxytetrahydro-β-Carboline in Elevating Brain Serotoninion whether low brain serotonin (5-HT) or norepinephrine (NE) is specifically responsible for this abnormal state. The evidence that elevating the level of brain 5-HT alleviates depression was first presented by Coppen, Shaw, and Farrell (1963). They reported that administration of tryptophan to dep