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Titlebook: Blood-Brain Barrier; Drug Delivery and Br David Kobiler,Shlomo Lustig,Shlomo Shapira Book 2001 Springer Science+Business Media New York 200

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Gene Transfer to the Salivary Glands: Applications in Gene Therapy,arry the saliva to the oral cavity and control its electrolyte composition. In addition to their essential roles in proper maintenance of the upper digestive system by exocrine secretion, salivary secreted endocrine proteins have been reported to affect distal tissues. Salivary proteins such as epid
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The Effect of Hyperosmotic Blood Brain Barrier Disruption on Experimental Autoimmune Encephalomyelige in BBB integrity during immune insults may contribute to the immunopathological process by attracting humoral and cellular effectors, thereby causing a propagation of the disease. Furthermore, in any tentative treatment suggested for the relief of the inflammation in the CNS, there is always the
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Bifurcation Problems of Basic Equations,7). Our initial studies demonstrated that NO was involved in the postischemic hypoperfusion observed in animal models of cerebral ischemia (Spatz, .,1995b). This effect was related to increased levels of ET-1 in the cerebrospinal fluid (CSF). Treatment with ET-1 receptor antagonists abolished the hy
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Limit States of Materials and Structuresult in increased or decreased paracellular and/or transcellular transport of compounds to the brain. Under such conditions, upregulated transcellular transport may provide a key to target drugs selectively to the BBB and subsequently into the brain. In the BBB Research Group of the Division of Pharm
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Limit States of Materials and Structuresl transiently open the BBB and facilitate entry of a particular drug or agent to the brain (Abbot). Modulation of the BBB with bioactive molecules in contrast to osmotic disruption is appearing as an effective technique. Some limited clinical success has been reported with this approach in the perme
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Shoumei Li,Yukio Ogura,Vladik Kreinovichere neurotoxicity (Coffey .,1984; Linstedt .,1997), while others have reported no neurotoxicity at all (Shifrin .,1990; Dimakakos .,1998; Hawkins and Caridi, 1998). Interpretation of these inconsistent results is complicated by the fact that most have not used a systematic experimental approach, wit
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Shoumei Li,Yukio Ogura,Vladik Kreinovichition, fatigue, sleep disturbance, confusion), which could not be easily explained by the effects of a compound that does not enter the CNS. The controversy around the “Gulf war syndrome” was further complicated by the suggestion that stress exposure (physical conditions, combat related anxiety, per
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Limit Theorems for Random Fields,for example AIDS dementia; with hydrocephalus, for example mumps virus in children; with neurodegenerative disease, for example spongiform degeneration with murine (Cas-Br-E) retroviruses; with neuro-developmental abnormalities, for example rubella virus or feline panleukopenia virus and cerebellar
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